From brainmatrix

CBD liver damage:[edit]

A few years back, a drug that used a part of CBD in super high doses did cause liver damage in some patients. (epidiolex study)[1]

High-dose CBD (≥1000 mg/day or ≥20 mg/kg/day) and concomitant antiepileptic drug use were identified as risk factors. No cases were reported in adults using cannabidiol doses <300 mg/day.


Does CBD cause liver enzyme increase in adults with high doses: CBD (1,500 mg/day)[2]


But a recent study looked at natural CBD taken at normal doses and found no issues. The couple of people who did have liver issues were due to other medications and past medical history or conditions like liver disease.[3]



  1. Lo, Lindsay A.; Christiansen, April; Eadie, Lauren; Strickland, Justin C.; Kim, David D.; Boivin, Michael; Barr, Alasdair M.; MacCallum, Caroline A. (2023). "Cannabidiol-Associated Hepatotoxicity: A Systematic Review and Meta-Analysis". J. Intern Med. 293: 724–752. doi:doi: 10.1111/joim.13627 Check |doi= value (help). ISSN 1556-5068.
  2. Watkins, Paul B.; Church, Rachel J.; Li, Jie; Knappertz, Volker (2020). "Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial". Clinical Pharmacology & Therapeutics. 109 (5): 1224–1231. doi:10.1002/cpt.2071. ISSN 0009-9236. PMC 8246741 Check |pmc= value (help). PMID 33022751 Check |pmid= value (help).
  3. Kaufmann, Robert; Aqua, Keith; Lombardo, Jeff; Lee, Martin (2023). "Observed Impact of Long-Term Consumption of Oral Cannabidiol on Liver Function in Healthy Adults". Cannabis and Cannabinoid Research. 8 (1): 148–154. doi:10.1089/can.2021.0114. ISSN 2578-5125. PMC 9940803 Check |pmc= value (help). PMID 34918948 Check |pmid= value (help).