Mood Disorders

From brainmatrix

DEPRESSION[edit]

Etiologies[edit]

Inflammation[edit]

- in adolescent depression: https://www.dovepress.com/evaluation-of-inflammatory-response-system-irs-and-compensatory-immune-peer-reviewed-fulltext-article-JIR

Low HDL-C[edit]

study of 41 patients with bipolar disorder, 34 patients with major depression, or controls[1]

results showed:

- all patients had significantly lower HDL-C values than control subjects

- Increased TG levels were found in patients with bipolar disorder compared to healthy subjects.

- no differences in the cholestrol and LDL-C levels and body mass index

- significant differences in the ratios of cholesterol/HDL-C and LDL- C/HDL-C values (atherogenic index) among groups.

- conclusion: low HDL-C levels and high atherogenic index might be a hallmark of affective disorders

RECOMMENDATIONS:[edit]

supplements[edit]

amino acids[edit]
carnitine[edit]

-may be a biomarker https://pubmed.ncbi.nlm.nih.gov/34658942/

vitamins[edit]
vitamin D[edit]

- Increased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks−1) resulted in a significant decrease in BDI-II scores in patients with mild to moderate depression. However, this effect was independent of the serum concentrations of the studied inflammatory biomarkers. [2]

botanicals[edit]
rauwolfia[edit]

- used for the treatment of hypertension, it may be contraindicated due to lowering of catecholamines and neurotransmitters https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566472/

fish Oil:[edit]

- EPA 4 g/d in MDD demonstrated a medium effect size for response rates versus placebo in overweight individuals with elevated inflammatory markers, and change in hs-CRP may be correlated with clinical response. [3]

Depression[edit]

Dysthymia[edit]

Bipolar disorder[edit]

Etiologies:[edit]

Low HDL-C:[edit]

study of 41 patients with bipolar disorder, 34 patients with major depression, or controls[1]

results showed:

- all patients had significantly lower HDL-C values than control subjects

- Increased TG levels were found in patients with bipolar disorder compared to healthy subjects.

- no differences in the cholestrol and LDL-C levels and body mass index

- significant differences in the ratios of cholesterol/HDL-C and LDL- C/HDL-C values (atherogenic index) among groups.

- conclusion: low HDL-C levels and high atherogenic index might be a hallmark of affective disorders

SUPPLEMENTS:

- Lithium orotate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413749/

Mood disorder due to a general medical condition and substance-induced mood disorder[edit]

PMDD[edit]

- low 5a-pregnanediol can be a contributing factor to PMDD and irritability due to issues with the GABA receptor's inability to adjust for sensitivity to fluctuating neurosteroids . This metabolite can cross the blood-brain-barrier and binds to GABA receptors, supporting a calming effect. Women who metabolize their progesterone through this pathway with lower levels of 5a-pregnanediol may benefit best from oral progesterone for symptoms of anxiety and difficulty sleeping .[4]

  1. 1.0 1.1 Sagud, Marina; Mihaljevic-Peles, Alma; Pivac, Nela; Jakovljevic, Miro; Muck-Seler, Dorotea (2009-08-15). "Lipid levels in female patients with affective disorders". Psychiatry Research. 168 (3): 218–221. doi:10.1016/j.psychres.2008.06.048. ISSN 0165-1781. PMID 19560828.
  2. Kaviani, Mina; Nikooyeh, Bahareh; Etesam, Farnaz; Behnagh, Siroos Jahangiri; Kangarani, Hamed Mohammadi; Arefi, Mohammad; Yaghmaei, Parichehreh; Neyestani, Tirang R. (2022-11-11). "Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial". BMC Psychiatry. 22 (1): 694. doi:10.1186/s12888-022-04305-3. ISSN 1471-244X.
  3. Mischoulon, David; Dunlop, Boadie W.; Kinkead, Becky; Schettler, Pamela J.; Lamon-Fava, Stefania; Rakofsky, Jeffrey J.; Nierenberg, Andrew A.; Clain, Alisabet J.; Mletzko Crowe, Tanja; Wong, Andrea; Felger, Jennifer C. (2022-08-22). "Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial". The Journal of Clinical Psychiatry. 83 (5): 21m14074. doi:10.4088/JCP.21m14074. ISSN 1555-2101. PMID 36005883 Check |pmid= value (help).
  4. DUTCH Test, lab description (Dr. Briden)