Pregnancy

Women who used serotonin reuptake inhibitors are over 200% as likely to experience preterm premature rupture of membranes (PPROM) compared to women who did not take these medications.^[1] Thirteen percent of pregnant women use antidepressants. Serotonin reuptake inhibitor antidepressants provoke an inflammatory response by increasing p38-MAPK activity, specifically in the amniotic sac of human fetal membranes contributing to an early 'water breaking.' ^[2]

↑ Yonkers, Kimberly A.; Norwitz, Errol R.; Smith, Megan V.; Lockwood, Charles J.; Gotman, Nathan; Luchansky, Edward; Lin, Haiqun; Belanger, Kathleen (2012-09). "Depression and serotonin reuptake inhibitor treatment as risk factors for preterm birth". Epidemiology (Cambridge, Mass.). 23 (5): 677–685. doi:10.1097/EDE.0b013e31825838e9. ISSN 1531-5487. PMC 3415566. PMID 22627901. Check date values in: |date= (help)
↑ Fabrizio, Veronica A.; Lindsay, Christina V.; Wilcox, Maya; Hong, Suyeon; Lynn, Tatyana; Norwitz, Errol R.; Yonkers, Kimberly A.; Abrahams, Vikki M. (2023-02-01). "The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation". Journal of Reproductive Immunology. 155: 103786. doi:10.1016/j.jri.2022.103786. ISSN 0165-0378.

[1] Yonkers, Kimberly A.; Norwitz, Errol R.; Smith, Megan V.; Lockwood, Charles J.; Gotman, Nathan; Luchansky, Edward; Lin, Haiqun; Belanger, Kathleen (2012-09). "Depression and serotonin reuptake inhibitor treatment as risk factors for preterm birth". Epidemiology (Cambridge, Mass.). 23 (5): 677–685. doi:10.1097/EDE.0b013e31825838e9. ISSN 1531-5487. PMC 3415566. PMID 22627901. Check date values in: |date= (help)

[2] Fabrizio, Veronica A.; Lindsay, Christina V.; Wilcox, Maya; Hong, Suyeon; Lynn, Tatyana; Norwitz, Errol R.; Yonkers, Kimberly A.; Abrahams, Vikki M. (2023-02-01). "The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation". Journal of Reproductive Immunology. 155: 103786. doi:10.1016/j.jri.2022.103786. ISSN 0165-0378.

[1]

[2]