Supplements

From brainmatrix

Supplements:[edit]

AMINO ACIDS:[edit]

L-Carnitine:[edit]

- Low levels associated with depression[1]

SAMe :[edit]

- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [2]


MINERALS[edit]

Lithium orotate:[edit]

- For bipolar disorder[3]: 

VITAMINS:[edit]

vitamin D[edit]

- Increased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks−1) resulted in a significant decrease in BDI-II scores in patients with mild to moderate depression. However, this effect was independent of the serum concentrations of the studied inflammatory biomarkers. [4]

FATTY ACIDS:[edit]

Fish Oil:[edit]

- EPA 4 g/d in MDD demonstrated a medium effect size for response rates versus placebo in overweight individuals with elevated inflammatory markers, and change in hs-CRP may be correlated with clinical response. [5]

HORMONAL SUPPLEMENTS[edit]

Progesterone[edit]

- low 5a-pregnanediol can be a contributing factor to PMDD and irritability due to issues with the GABA receptor's inability to adjust for sensitivity to fluctuating neurosteroids . This metabolite can cross the blood-brain-barrier and binds to GABA receptors, supporting a calming effect. Women who metabolize their progesterone through this pathway with lower levels of 5a-pregnanediol may benefit best from oral progesterone for symptoms of anxiety and difficulty sleeping .[6]

Melatonin[edit]

- Melatonin for Psychitric Disorders: Melatonin is promising for the correction of sleep and circadian abnormalities in psychiatric disorders.[7]

- Melatonin with Methylphenidate to help sleep in ADHD[8]:

BOTANICAL MEDICINES / HERBS:[edit]

Maca:[edit]

- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [9]

Saffron:[edit]

- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [10]


DRUG SUPPLEMENT INTERACTIONS[edit]

Beneficial Interactions:[edit]

Mirtazepine with Melatonin: [11][edit]

- Melatonin has been studied with Methylphenidate to help sleep concerns in ADHD[8][edit]
- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [12][edit]

Negative Interactions:[edit]

References[edit]

  1. ↑ Nie, Li-Juan; Liang, Jun; Shan, Feng; Wang, Bao-Shi; Mu, Yuan-Yuan; Zhou, Xie-Hai; Xia, Qing-Rong (2021). "L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder". Frontiers in Psychiatry. 12: 671151. doi:10.3389/fpsyt.2021.671151. ISSN 1664-0640. PMC 8514700 Check |pmc= value (help). PMID 34658942 Check |pmid= value (help).
  2. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
  3. ↑ Pacholko, Anthony G.; Bekar, Lane K. (2021). "Lithium orotate: A superior option for lithium therapy?". Brain and Behavior. 11 (8): e2262. doi:10.1002/brb3.2262. ISSN 2162-3279. PMC 8413749 Check |pmc= value (help). PMID 34196467 Check |pmid= value (help).
  4. ↑ Kaviani, Mina; Nikooyeh, Bahareh; Etesam, Farnaz; Behnagh, Siroos Jahangiri; Kangarani, Hamed Mohammadi; Arefi, Mohammad; Yaghmaei, Parichehreh; Neyestani, Tirang R. (2022-11-11). "Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial". BMC Psychiatry. 22 (1): 694. doi:10.1186/s12888-022-04305-3. ISSN 1471-244X.
  5. ↑ Mischoulon, David; Dunlop, Boadie W.; Kinkead, Becky; Schettler, Pamela J.; Lamon-Fava, Stefania; Rakofsky, Jeffrey J.; Nierenberg, Andrew A.; Clain, Alisabet J.; Mletzko Crowe, Tanja; Wong, Andrea; Felger, Jennifer C. (2022-08-22). "Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial". The Journal of Clinical Psychiatry. 83 (5): 21m14074. doi:10.4088/JCP.21m14074. ISSN 1555-2101. PMID 36005883 Check |pmid= value (help).
  6. ↑ DUTCH Test, lab description (Dr. Briden)
  7. ↑ Moon, Eunsoo; Kim, Kyungwon; Partonen, Timo; Linnaranta, Outi (2022). "Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness". Current Psychiatry Reports. 24 (11): 623–634. doi:10.1007/s11920-022-01369-6. ISSN 1535-1645.
  8. ↑ 8.0 8.1 Masi, Gabriele; Fantozzi, Pamela; Villafranca, Arianna; Tacchi, Annalisa; Ricci, Federica; Ruglioni, Laura; Inguaggiato, Emanuela; Pfanner, Chiara; Cortese, Samuele (2019). "Effects of melatonin in children with attention-deficit/hyperactivity disorder with sleep disorders after methylphenidate treatment". Neuropsychiatric Disease and Treatment. 15: 663–667. doi:10.2147/NDT.S193891. ISSN 1176-6328. PMC 6410756. PMID 30880992.
  9. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
  10. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
  11. ↑ Dolev, Zipora (2011). "Case series of perimenopausal women with insomnia treated with mirtazapine followed by prolonged-release melatonin add-on and monotherapy". Archives of Women's Mental Health. 14 (3): 269–273. doi:10.1007/s00737-011-0205-7. ISSN 1435-1102. PMID 21311927.
  12. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
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