Supplements

From brainmatrix

Supplements:[edit]

AMINO ACIDS:[edit]

L-Carnitine:[edit]

- Low levels associated with depression[1]

SAMe :[edit]

- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [2]

MINERALS[edit]

Lithium:[edit]

-For autism:[3]

- Research in JAMA pediatrics suggests that higher lithium levels are associated with autism.

https://jamanetwork.com/journals/jamapediatrics/article-abstract/2803171

Lithium orotate:[edit]

- For bipolar disorder:[4] 

The article is review of Lithium orotate.

- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413749/#

Zinc:[edit]

Zinc Intake Is Associated with Lower Cadmium Burden in U.S. Adults[5]

https://pubmed.ncbi.nlm.nih.gov/26491124/

Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure[6]

https://pubmed.ncbi.nlm.nih.gov/22959313/

Magnesium:[edit]

Magnesium and Borderline Personality Disorder (BPD)[7]

https://pubmed.ncbi.nlm.nih.gov/26978056/

Potassium:[edit]

DFH Potassium supplement: 300mg per capsule

Avocado  - 790mg

Banana  - 422mg

VITAMINS:[edit]

Vitamin C:[edit]

Vitamin C supports Norepinephrine:

- By supporting Tetrahydrobiopterin (BH4) and Tyrosine Hydroxylase:[8]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449284/

- vitamin C support Dopamine Beta Hydroxylase (DBH) activity to make more norepinephrine:[9]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527656/

Vitamin D[edit]

- Increased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks−1) resulted in a significant decrease in BDI-II scores in patients with mild to moderate depression. However, this effect was independent of the serum concentrations of the studied inflammatory biomarkers. [10]

- Current research suggests that Vitamin D supplementation (2000 IU/day) could could help alleviate symptoms of depression.

https://www.mdlinx.com/article/the-vitamin-that-affects-mood-and-may-help-with-depression/4SsgGvdsCXkamoDxp9hXBf?show_order=6&utm_campaign=reg_wellness-update_231015_wellness-update-nl_registered-users-a90&utm_source=iterable&utm_medium=email

Vitamin K[edit]

Borderline Personality Disorder and Vitamin K[11]

https://pubmed.ncbi.nlm.nih.gov/17853273/

FATTY ACIDS/Fish Oil:[edit]

Omega-3 Fatty Acids/Fish Oil:[edit]

- EPA 4 g/d in MDD demonstrated a medium effect size for response rates versus placebo in overweight individuals with elevated inflammatory markers, and change in hs-CRP may be correlated with clinical response. [12]

- Marine omega-3 fatty acids (fish oil) improves symptoms of Borderline Personality Disorder (BPD), such as impulsive behaviors and those related to affect dysregulation.[13]

https://pubmed.ncbi.nlm.nih.gov/34004088/

- Fish oil for adolescents with Borderline Personality Disorder (BPD)[14]

https://pubmed.ncbi.nlm.nih.gov/23870722/

- Benefits of Omega-3 and Omega-6 Fatty Acids in the treatment of Traumatic Brain Injury (TBI)[15]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518659/

HORMONAL SUPPLEMENTS[edit]

Progesterone[edit]

- low 5a-pregnanediol can be a contributing factor to PMDD and irritability due to issues with the GABA receptor's inability to adjust for sensitivity to fluctuating neurosteroids . This metabolite can cross the blood-brain-barrier and binds to GABA receptors, supporting a calming effect. Women who metabolize their progesterone through this pathway with lower levels of 5a-pregnanediol may benefit best from oral progesterone for symptoms of anxiety and difficulty sleeping .[16]

Melatonin[edit]

- Melatonin for Psychitric Disorders: Melatonin is promising for the correction of sleep and circadian abnormalities in psychiatric disorders.[17]

- Melatonin with Methylphenidate to help sleep in ADHD[18]:

Melatonin and leukemia:[19][20][21]

https://pubmed.ncbi.nlm.nih.gov/31713261/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057911/

https://www.degruyter.com/document/doi/10.1515/hmbci-2021-0009/html?lang=en

BOTANICAL MEDICINES / HERBS:[edit]

Maca:[edit]

- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [22]

Saffron:[edit]

- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [23]

Yi-Gan San:[edit]

Borderline Personality Disorder and Yi-Gan Sun, a traditional Chinese herbal medicine.[24][25]

https://pubmed.ncbi.nlm.nih.gov/17765378/

https://pubmed.ncbi.nlm.nih.gov/23094294/

Sage:[edit]

Sage for hyperhidrosis:[26][27]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567565/

https://pubmed.ncbi.nlm.nih.gov/6706577/

https://www.drweil.com/health-wellness/body-mind-spirit/disease-disorders/sage-for-excess-sweating/

Shepherd’s purse (Capsella bursa-pastoris):[edit]

Shepherd’s purse (Capsella bursa-pastoris): for heavy menses:[28]

https://pubmed.ncbi.nlm.nih.gov/29641247/

DRUG SUPPLEMENT INTERACTIONS[edit]

Beneficial Interactions:[edit]

Mirtazepine with Melatonin: [29][edit]

- Melatonin has been studied with Methylphenidate to help sleep concerns in ADHD[18]

- A number of nutraceuticals, including SAMe, Saffron, and high dose MACA may improve Antidepressant-Induced Sexual Dysfunctions (AISD)'s [30]


Negative Interactions:[edit]

References[edit]

  1. ↑ Nie, Li-Juan; Liang, Jun; Shan, Feng; Wang, Bao-Shi; Mu, Yuan-Yuan; Zhou, Xie-Hai; Xia, Qing-Rong (2021). "L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder". Frontiers in Psychiatry. 12: 671151. doi:10.3389/fpsyt.2021.671151. ISSN 1664-0640. PMC 8514700 Check |pmc= value (help). PMID 34658942 Check |pmid= value (help).
  2. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
  3. ↑ Liew, Zeyan; Meng, Qi; Yan, Qi; Schullehner, Jörg; Hansen, Birgitte; Kristiansen, Søren Munch; Voutchkova, Denitza D.; Olsen, Jørn; Ersbøll, Annette Kjær; Ketzel, Matthias; Raaschou-Nielsen, Ole (2023). "Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark". JAMA Pediatrics. 177 (6): 617. doi:10.1001/jamapediatrics.2023.0346. ISSN 2168-6203. PMC 10071398 Check |pmc= value (help). PMID 37010840 Check |pmid= value (help).
  4. ↑ Pacholko, Anthony G.; Bekar, Lane K. (2021). "Lithium orotate: A superior option for lithium therapy?". Brain and Behavior. 11 (8): e2262. doi:10.1002/brb3.2262. ISSN 2162-3279. PMC 8413749 Check |pmc= value (help). PMID 34196467 Check |pmid= value (help).
  5. ↑ Vance, T. M., & Chun, O. K. (2015). Zinc intake is associated with lower cadmium burden in US adults. The Journal of nutrition, 145(12), 2741-2748. PMID: 26491124 DOI: 10.3945/jn.115.223099
  6. ↑ McCarty, Mark F. (2012). "Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure". Medical Hypotheses. 79 (5): 642–648. doi:10.1016/j.mehy.2012.07.043. ISSN 0306-9877.
  7. ↑ Kopitsyna, U. E.; Grishina, T. R.; Torshin, I. Yu.; Kalacheva, A. G.; Gromova, O. A. (2015). "Very low magnesium levels in red blood cells as a significant factor in the etiopathogenesis of borderline disorders". Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 115 (11): 85. doi:10.17116/jnevro201511511185-96. ISSN 1997-7298.
  8. ↑ May, James M.; Qu, Zhi-chao; Meredith, M. Elizabeth (2012). "Mechanisms of ascorbic acid stimulation of norepinephrine synthesis in neuronal cells". Biochemical and Biophysical Research Communications. 426 (1): 148–152. doi:10.1016/j.bbrc.2012.08.054. ISSN 0006-291X. PMC 3449284. PMID 22925890.
  9. ↑ May, James M.; Qu, Zhi-chao; Nazarewicz, Rafal; Dikalov, Sergey (2013). "Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine". Brain Research Bulletin. 90: 35–42. doi:10.1016/j.brainresbull.2012.09.009. ISSN 0361-9230. PMC 3527656. PMID 23022576.
  10. ↑ Kaviani, Mina; Nikooyeh, Bahareh; Etesam, Farnaz; Behnagh, Siroos Jahangiri; Kangarani, Hamed Mohammadi; Arefi, Mohammad; Yaghmaei, Parichehreh; Neyestani, Tirang R. (2022). "Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial". BMC Psychiatry. 22 (1): 694. doi:10.1186/s12888-022-04305-3. ISSN 1471-244X.
  11. ↑ Malevani, J., Mobascher, J., Cordes, J., & Mobascher, A. (2008). Differential diagnosis of coagulation abnormalities in borderline personality disorder. The World Journal of Biological Psychiatry, 9(1), 78-80. PMID: 17853273 DOI: 10.1080/15622970701405532
  12. ↑ Mischoulon, David; Dunlop, Boadie W.; Kinkead, Becky; Schettler, Pamela J.; Lamon-Fava, Stefania; Rakofsky, Jeffrey J.; Nierenberg, Andrew A.; Clain, Alisabet J.; Mletzko Crowe, Tanja; Wong, Andrea; Felger, Jennifer C. (2022). "Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial". The Journal of Clinical Psychiatry. 83 (5): 21m14074. doi:10.4088/JCP.21m14074. ISSN 1555-2101. PMID 36005883 Check |pmid= value (help).
  13. ↑ Karaszewska, Dominika M.; Ingenhoven, Theo; Mocking, Roel J. T. (2021). "Marine Omega-3 Fatty Acid Supplementation for Borderline Personality Disorder". The Journal of Clinical Psychiatry. 82 (3). doi:10.4088/jcp.20r13613. ISSN 1555-2101.
  14. ↑ Amminger, G Paul; Chanen, Andrew M; Ohmann, Susanne; Klier, Claudia M; Mossaheb, Nilufar; Bechdolf, Andreas; Nelson, Barnaby; Thompson, Andrew; McGorry, Patrick D; Yung, Alison R; Schäfer, Miriam R (2013). "Omega-3 Fatty Acid Supplementation in Adolescents with Borderline Personality Disorder and Ultra-High Risk Criteria for Psychosis: A Post Hoc Subgroup Analysis of a Double—Blind, Randomized Controlled Trial". The Canadian Journal of Psychiatry. 58 (7): 402–408. doi:10.1177/070674371305800705. ISSN 0706-7437.
  15. ↑ Lewis, Michael; Ghassemi, Parviz; Hibbeln, Joseph (2013). "Therapeutic use of omega-3 fatty acids in severe head trauma". The American Journal of Emergency Medicine. 31 (1): 273.e5–273.e8. doi:10.1016/j.ajem.2012.05.014. ISSN 0735-6757. PMC 3518659. PMID 22867826.
  16. ↑ DUTCH Test, lab description (Dr. Briden)
  17. ↑ Moon, Eunsoo; Kim, Kyungwon; Partonen, Timo; Linnaranta, Outi (2022). "Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness". Current Psychiatry Reports. 24 (11): 623–634. doi:10.1007/s11920-022-01369-6. ISSN 1535-1645.
  18. ↑ 18.0 18.1 Masi, Gabriele; Fantozzi, Pamela; Villafranca, Arianna; Tacchi, Annalisa; Ricci, Federica; Ruglioni, Laura; Inguaggiato, Emanuela; Pfanner, Chiara; Cortese, Samuele (2019). "Effects of melatonin in children with attention-deficit/hyperactivity disorder with sleep disorders after methylphenidate treatment". Neuropsychiatric Disease and Treatment. 15: 663–667. doi:10.2147/NDT.S193891. ISSN 1176-6328. PMC 6410756. PMID 30880992.
  19. ↑ Shafabakhsh, Rana; Mirzaei, Hamed; Asemi, Zatollah (2019). "Melatonin: A promising agent targeting leukemia". Journal of Cellular Biochemistry. 121 (4): 2730–2738. doi:10.1002/jcb.29495. ISSN 0730-2312.
  20. ↑ Li, Tian; Yang, Zhi; Jiang, Shuai; Di, Wencheng; Ma, Zhiqiang; Hu, Wei; Chen, Fulin; Reiter, Russel J; Yang, Yang (2017). "Melatonin: does it have utility in the treatment of haematological neoplasms?". British Journal of Pharmacology. 175 (16): 3251–3262. doi:10.1111/bph.13966. ISSN 0007-1188. PMC 6057911. PMID 28880375.
  21. ↑ Ng, Ming Guan; Ng, Khuen Yen; Koh, Rhun Yian; Chye, Soi Moi (2021). "Potential role of melatonin in prevention and treatment of leukaemia". Hormone Molecular Biology and Clinical Investigation. 42 (4): 445–461. doi:10.1515/hmbci-2021-0009. ISSN 1868-1891.
  22. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
  23. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
  24. ↑ Miyaoka, Tsuyshi; Furuya, Motohide; Yasuda, Hideaki; Hayashia, Maiko; Inagaki, Takuji; Horiguchi, Jun (2008). "Yi-gan san for the treatment of borderline personality disorder: An open-label study". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32 (1): 150–154. doi:10.1016/j.pnpbp.2007.07.026. ISSN 0278-5846.
  25. ↑ Horiguchi, J. (2012). Clinical usage of Yi-gan san-schizophrenia, borderline personality disorder, dyskinesia etc. Seishin Shinkeigaku Zasshi= Psychiatria et Neurologia Japonica, 114(6), 708-718. PMID: 23094294
  26. ↑ Tober, Carsten; Schoop, Roland (2019). "Modulation of neurological pathways by Salvia officinalis and its dependence on manufacturing process and plant parts used". BMC Complementary and Alternative Medicine. 19 (1). doi:10.1186/s12906-019-2549-x. ISSN 1472-6882. PMC 6567565. PMID 31196061.
  27. ↑ Hölze, E. (1984). Therapy of hyperhidrosis. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und Verwandte Gebiete, 35(1), 7-15. PMID: 6706577https://europepmc.org/article/med/6706577
  28. ↑ Naafe, Mahdis; Kariman, Nourossadat; Keshavarz, Zohreh; Khademi, Nasim; Mojab, Faraz; Mohammadbeigi, Abolfazl (2018). "Effect of Hydroalcoholic Extracts of Capsella Bursa-Pastoris on Heavy Menstrual Bleeding: A Randomized Clinical Trial". The Journal of Alternative and Complementary Medicine. 24 (7): 694–700. doi:10.1089/acm.2017.0267. ISSN 1075-5535.
  29. ↑ Dolev, Zipora (2011). "Case series of perimenopausal women with insomnia treated with mirtazapine followed by prolonged-release melatonin add-on and monotherapy". Archives of Women's Mental Health. 14 (3): 269–273. doi:10.1007/s00737-011-0205-7. ISSN 1435-1102. PMID 21311927.
  30. ↑ Concerto, Carmen; Rodolico, Alessandro; Meo, Valeria; Chiappetta, Donatella; Bonelli, Marina; Mineo, Ludovico; Saitta, Giulia; Stuto, Sebastiano; Signorelli, Maria Salvina; Petralia, Antonino; Lanza, Giuseppe (2022-07-25). "A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications". Current Issues in Molecular Biology. 44 (8): 3335–3350. doi:10.3390/cimb44080230. ISSN 1467-3045. PMC 9332380 Check |pmc= value (help). PMID 35892716 Check |pmid= value (help).
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